Sildenafil: Dosage, Efficacy, and Formulations

• Dosage: Sildenafil is available in doses of 25, 50, and 100 mg. The recommended starting dose is 50 mg, which can be adjusted according to efficacy and tolerability [385].

• Onset and duration: The drug is effective within 30–60 minutes of administration [385], with efficacy lasting up to 12 hours [386].

• Clinical efficacy: In a 24-week dose-response study, improved erections were reported by:

  • 56% of men taking 25 mg,

  • 77% with 50 mg,

  • 84% with 100 mg,compared to 25% in the placebo group [387].

• Validated outcomes: Sildenafil significantly improved scores on the IIEF, SEP2, SEP3, GAQ, and overall treatment satisfaction [387].

• Novel formulations:

  • An orally disintegrating tablet (ODT) version of sildenafil citrate has been developed at doses of 25, 50, 75, and 100 mg, targeting patients with swallowing difficulties [388].

  • A sildenafil oral suspension has also been introduced, demonstrating clinically relevant results.

  • https://uroweb.org/guidelines/sexual-and-reproductive-health/chapter/management-of-erectile-dysfunction#:~:text=5.6.3.1.%20Sildenafil,%2C2001%5D.